Dennis Cockrum as Terry Milkovich - The father of Mickey and Mandy Milkovich. He is known to have escaped arrest numerous times, which causes Frank to turn to him when he needs a water-tight alibi to stop the police questioning him about the death of Eddie Jackson. He also very nearly catches Ian and Mickey together, but assumes the pair have been on drugs and thinks nothing of it. It is later discovered, due to his constant drinking and blackouts he has unknowingly impregnated his daughter Mandy. Possibly a regular cast in Season 3.

Marguerite Moreau as Linda Karib - She is the wife of Kash and is a proud white Muslim. She is shown as a business-minded busybody. She treats everything like a business, including her marriage. When she discovers her husband has been having a gay affair, she accepts it on the basis that he gives her another child. Kash later leaves Linda pregnant and alone.

Anthony Anderson as Marty Fisher (US) (Season 1). He is the brother of Veronica Fisher (US) and the son of Carol Fisher (US).

Missy Doty as Jess - The lesbian bartender at the Alibi Room. Jess seems witty and has a dry sense of humor, she takes charge of the books at the Alibi, unaware that it's because Kevin can't read. The two often clash over Stan (The business owner), who is slowly losing his mental faculties. She pushes for Kevin to phone his daughter and have him put in a home, yet Kevin seems reluctant.

Zach McGowan as Jody Silverman - A man Karen meets at Sex Addicts Anonymous and later marries. Jody is a keen tattoo artist, often seen looking for work and helping around the house. He becomes extremely attached to Sheila calling her 'Mom', but is unaware that Karen breaks her celibacy and is cheating on him with Lip. When Karen falls pregnant, she tells Lip that Jody will be the father, but when he becomes too overbearing she kicks him out (not before making him sign a pre-nuptial agreement first) .

Louise Fletcher as Peg Gallagher - Also known as 'Grammy' she is the formidable mother of Frank and matriarch of the Gallagher family, being sent home from prison after lying about her health. Immediately she goes after an old dealer who profited from her arrest and demands money from him, which Frank ends up ruining. The mother and son are shown to have a frosty relationship and she soon makes an enemy from Sheila, who she even tries to shoot. Despite her hostile nature, she tries her best to reach out to the Gallagher children, giving Fiona money and showering Carl and Debbie with gifts. However, when Peg tries to run a meth lab in the basement, Fiona and Frank plot to get rid of her only to discover that she really is dying of cancer and hasn't got long to live. She eventually dies.