|Portrayed By||Laura Slade Wiggins|
|Season||1 - Present|
Karen Jackson is the only child of Sheila and Eddie Jackson. Her mother Sheila became agoraphobic sometime during her childhood, which at times can negatively affect their relationship. In the episode Nana Gallagher had an Affair, Karen explains that she lost her virginity when she was in eighth grade, and has been sexually active ever since.
In Season 1, she is Lip's tutoring student and the neighborhood bad girl. Apparently, "science just turns her on" and she was happy to repay Lip's tutoring with sexual favors. Karen's father leaves after catching her giving oral sex to Ian. Which she was only doing for Lip to see if Ian was actually gay. Karen and Lip develop a sexual relationship, with Lip clearly falling in love with her, but she refuses to be his girlfriend. Eddie ends up taking Karen to his church's purity ball in hopes of getting her to stop having sex. She agrees to go in exchange for a car, but ends up getting called a whore by her own father when she admits her sexual history.
In Season 2, Karen was with a guy named Jody who's was from her Sex Addicts Anonymous class and marries him, but after a while when Lip's love for Karen drives him when he tries to investigate Karen she begins to ask Lip to get rid of Jody for her. Karen became pregnant with many thinking Lip was the father. However, it was revealed that Karen herself did not know the father of the baby though she assumed it was one of her old teachers. Karen decided that she was going to sell the baby, going to extreme lengths to find someone interested and willing to pay the most money, despite Lip's pleas for the baby to go to a good home. In the penultimate episode of Season 2 Just Like the Pilgrims Intended, Karen gave birth to the child, and to Lip's surprise, it is not his. The baby is of Asian-American descent, and to their dismay, has Down Syndrome. Lip exited the delivery room and told the would-be adoptive parents the situation, with their reaction suggesting they no longer wanted the child. At the end of the episode, Sheila abducted the baby from the hospital.
Karen gave Sheila an ultimatum, that her mother choose between the baby or Karen. Sheila pleaded with Karen but she was unable to change her daughters mind so decided to keep the child. Karen kept her word and left her mother's home in response. Her son is name Hyme, a name given by her mother Sheila.
In the episode "A Long Way from Home" Hymie's biological father and paternal grandmother show up at Sheila's home to take Hymie. Sheila is initially resistant, but eventually decides that her home is not a proper place to raise Hyme because of her boyfriend's (Jody) kinky sex acts (for which he previously attended Sex Addicts Anonymous for). Sheila allows Hymie's father to take Hyme. Later in the episode, Karen returns home. She apologizes to Sheila for leaving and for making Sheila choose between her and Hymie. She expresses interest in Hymie, and implies that she came back for him. However, it is later revealed that Karen contacted Hymie's father and told him to take Hymie away from Sheila. Karen claims that this was intended to help her and her mother get back to the way things were before Hymie was born.
Karen begins to be frustrated when her mom doesn't speak with her. Around this time Sheila gets some pep talk about her relationship with her daughter. Karen still having sexual lust for Lip begins to show, but Lip decided Mandy over Karen. She gest upset calls Mandy over the phone about sexual things and Lip, Mandy didn't take it well. Mandy sends a text from Lip's phone and tells her to meet up in the park. Karen with some excitement, after an apology from her mom, she desides to go and meet up with him. As she walks at the intersection a car passed by and she puts the middle finger at the car, only to turn around and Mandy runs her car over Karen and she flips over and lands on the ground. She is still alive as she is in the hospital bed in the next episode. Lip visited twice with Debbie and then alone. Lip discovered that someone used his phone to text Karen. Sheila explained the Karen lighted up when she got it that it made her excited that she didn't look both ways. However, Lip asked if he could look at the phone. Lip sees the text on a blood cover phone and ponders. He sits on the bus wondering even more. Afterwards, Jody tells Sheila that they need to watch her one at a time, and that she needs rest on an actual bed. Sheila agrees. Remebering what Lip said earlier about using things Karen likes to being her out of her coma, Jody starts giving her oral sex which results with Karen waking up. Apparently, Jody claims to have discovered a cure for the coma as he explain to the doctors about what had happened.
After she awoke from her medically induced coma, Karen's personality dramatically changed. Acording to Jody, she can only recall memories, but cannot make any more memories; she also answers most questions in monosyllables. Lip visits her and she can still recall him and a few other memories Lip mentions on his next visits. Sheila notes Karen seems so much "happier", presumably because her old personality is gone. Lip reveals to Karen that it was Mandy who ran her over and Karen amicably digests the news. She then follows up claiming she does not know who hit her. She is able to barely pronounce Mandy's name. Sheila also mentions to Lip that Jody and Karen are set to go to Arizona state to help Karen recover and will bring Himey along. Lip doesn't appear to react to Shelia upon hearing Karen is leaving, possibly forever but it's obvious any chance of a future he had with Karen is gone forever.
She leaves at the beginning of the episode along side Jody and baby Hymie as she is strapped onto a wheel chair, leaving Sheila alone.