Over the course of the series, a number of former regular characters have died. Most of them onscreen.
Kash Karib: Returned to Chatsworth in Episode 614, after having first faked his death in Episode 404. After attempting to extort his ex-wife for money, Yvonne and Stan Waterman conspired to kill him. However, Kash had overheard them, and went to what was then the Cash and Carry (later Chesco) and met with his estranged son, Chesney, who, in a moment of rage, knocked out his father. But an accidental fire in the stock room caused Chesney to flee from the shop, where the increased smoke resulted in Kash's death by suffocation.
Mandy Maguire: Died in a gas explosion caused by Maureen Tudor in Episode 616, who blamed Paddy for her own daughter's death from a heroin overdose.
Joseph Pritchard: Suffered several fatal blows to the back of the skull by Ian Gallagher, who used a tire iron when Joe was strangling Karen Maguire in Episode 716.
Carol Fisher: It was revealed in Episode 817 that Carol had died sometime after her departure from Chatsworth after Series 4, when her son, Marty, possessed an urn filled with her ashes. The details of her death were never revealed.
Ruby Hepburn: After her aunt Mimi says some unkind things about her father, Kenny Murphy (Mimi's late older brother) Ruby loses her temper, takes Mimi hostage and locks them both in her bedroom, with Billy Tutton and Jamie Maguire outside trying to talk her out of anything rash. But an attempt to block the door backfires when she is accidently pushed out the bedroom window to her death in Episode 10.10. Ruby's death would be covered up by the Maguire family.
Patty Croker: Was revealed to be dying of cancer late in Series 10. In Episode 10.10, Frank agreed to take her to the coast, so she could view the Irish coast from the horizon. Frank left Patty on the beach at low tide to help her get a better view, and told her he would return in an hour. But Frank delays by getting drunk. The next morning, Frank remembers where he had left Patty, and to his horror, finds her wheelchair vacated and half-buried in the sand.
Joan Dallimore: Died from overdosing on pills after meeting with Monica Gallagher, her daughter, for the last time in Episode 609.
Maureen Tudor: Killed herself in a gas explosion, along with Paddy Maguire's daughter, Mandy, to get revenge on him, in Episode 616.
Steve "Bonehead" Boneden: A local youth who died from his injuries after he was savagely assaulted by Jimmy Dee, in retaliation for Bonehead sexually assaulting Jimmy's younger sister, and texting pictures of himself doing so.
Jimmy Dee: Leader of a small gang in Chatsworth, who threatened to kill the Gallagher's when Carl Gallagher and Chesney Karib attempted to inform the police after witnessing Jimmy killed a local youth. Jimmy was secretly killed by Joe Pritchard, after Jimmy's rampage was getting out of hand in Episode 710.
Homer: Kelly Marie Ball's father, who, in Episode 713, came to check up on Kelly's fifteen year old half-sister, Tonya, and her son Enrique. He was dismembered, in secret, by Mickey Maguire after Mickey had learned that Homer had in the past, raped both his daughters.
Reggie: An 84 year old WW2 RAF veteran, whom Liam made friends with in Episode 711. Reggie had been sick for a long time and would later die from his ailments in the episode.
Stanton: An elderly disabled man, whom Aidan Croker briefly did care-work for in Series 11. It would later be revealed that Aidan, at Stanton's urging, assisted in his suicide.
Baxter: Derilee's husband, whom held Frank, Derilee, Stella and Monica hostage in Episode 11.13. By the end of the episode, Derilee, who had suffered abuse for years at the hands of her husband, grabbed the gun and shot Baxter dead, ending the stand-off with the police.
Ferghal Maguire: In Episode 403, severed hand was sent to the Maguire family. Jamie Maguire recognised from the tattoo etched along the bottome wrist that the hand belonged to Ferghal. The Maguires would hold a private service beneath a canal bridge for Ferghal, before plotting their revenge on those they believed responsible. But Jamie talked his father, Paddy, out of any rash action. Ferghal Maguire was not a named character prior to the report of his death in this episode, and may have been present as one of the Maguire sons who were pursuing Ian way back in Episode 103.
Frank Gallagher: In Episode 107, on the advice of Norma Starkey and Monica Gallagher, Frank faked his death to escape creditors, even organising a funeral in their presence. Frank's death was even reported in the local news.
Kash Karib: At Yvonne's insistance, Kash wrote a suicide note for his family to read and disappeared from Manchester in Episode 404, after his reckless spending as a councillor for Chatsworth landed him and Yvonne in serious debt. Although, he would return several years later and die for real (see above).
Debbie Gallagher: In Episode 801, Monica made the Gallagher's believe Debbie was killed in Afghanistan, so she could return to them while they were still in a state of shock. Her cynical scheme, however, was soon revealed when Debbie successfully contacted Mickey Maguire, who relayed the message to Debbie's father and brothers.
Paddy Maguire: In Episode 716, it was implied by Joe Pritchard that he had relatives of his in Ireland go kill Paddy Maguire soon after he returned to Belfast. But there was no confirmation of this by the Maguires. However, in Episode 814, Paddy's coffin was carried to his old address in Chatsworth, where a crowd of local residents were openly celebrating. But, once behind closed doors, the coffin was opened to reveal a cache of firearms which had been purchased by Paddy from the IRA. The Maguires revealed that Paddy had faked his death to the authorities, and had retired to Thailand, rich from the profits he made after his departure from Manchester.
Sue Garland and her Children: In Episode 819, Shane discovered there was manhunt for Marty Fisher, who was believed to be the main suspect in an arson attack in Spain, which was said to have claimed the lives of Sue and her children with Marty. However, it was revealed much later in Episode 10.6, that Sue and her children were in fact alive and well, when Marty's son (the Romanian orphan baby from Episode 401) sent a letter to Marty Fisher, asking him when he would return. The details of this storyline were never revealed, however.