Having not had a boyfriend since Lip, Mandy agrees to go on a blind date with one of Jamie's friends though it is later revealed Jamie and Ian put Mandy's picture on an internet dating website. Even thought she is angry at first, Mandy and her new love Dex enjoy the evening and go back to The Jockey for a night of passion. However, when Dex appears to have died after Ecstasy fueled sex Mandy and Karen have a corpe on their hands. But when Paddy and Jamie discover Dex's death might be connected to their new batch of Ecstasy, Jamie makes sure that his family is protected by bribing Frank into thinking he was the last person to see Dex in with free alcohol. However, they are shocked to discover Dex is still alive though he dumps Mandy for thinking he was dead and dumping him in a ditch.
When Yvonne ruins his party by uncovering a stash of drugs, Chesney begins getting supplies from the Maguires and strikes up a friendship with Paddy and Mimi in the process. Later, Mimi gets worried when Chesney takes a turn for the worst after taking one of the possibly tainted Ecstasy pills and though Chesney recovers Mimi gets into a big argument with Yvonne. After some harsh words from Chesney, Yvonne and Mimi decide to make peace by having an evening in with Paddy and Stan.
Shane starts working at the shop with Yvonne and Carl only to find himself falling for Yvonne. Norma becomes a barmaid at The Jockey in Jamie's absence. Micky plans a party in his limo but with only Lillian and Ian attending it doesn't go as planned.
- David Threlfall - Frank Gallagher
- Gerard Kearns - Ian Gallagher
- Elliott Tittensor - Carl Gallagher
- Sean Glider - Paddy Maguire
- Tina Malone - Mimi Maguire
- Nicky Evans - Shane Maguire
- Rebecca Atkinson - Karen Maguire
- Ciaran Griffiths - Micky Maguire
- Samantha Siddall - Mandy Maguire
- Kelli Hollis - Yvonne Karib
- Qasim Akhtar - Chesney Karib
- Sarah Byrne - Meena Karib
- Warren Donnelly - PC Stan Waterman
- Alice Barry - Lillian Tyler
- Dystin Johnson - Norma Starkey
- Jamie Belman - Dex
- Narrator: Mandy Maguire. This is the first and only episode of Shameless to be narrated by Mandy.
- This is the first episode where the majority of the Gallagher family, except for Frank, Carl and Ian, were absent.